
Days 1-5 — The High Desert & Canyons
~400–600 mi across this legEstablish a steady pace as you explore massive natural wonders, historic engineering feats, and classic Americana before dipping into Route 66 nostalgia.
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| Duration | 22 Days |
| Distance | 3,047 mi |
| Start / End | Los Angeles or Las Vegas / Tampa |
| States Crossed | Arizona, Florida, Louisiana, Mississippi, Nevada, New Mexico, Texas |
| Best For | Families, History Buffs, Nature Lovers |
Taking a cross-country motorhome road trip from Las Vegas to Tampa is a remarkable way to experience the shifting landscapes of the American Southwest and Southeast. Over the course of 22 days, you transition from the neon lights and arid deserts of Nevada to the lush, humid coastlines of Florida. This extended timeline is the perfect recipe for slow travel, allowing you to settle into the rhythm of the road without feeling rushed.
Because this route spans 3,047 mi and crosses seven unique states, traveling by RV ensures you have your home base with you at all times. Whether you are navigating the vast stretches of the Texas plains or winding through the red rocks of Arizona, an RV provides the comfort, flexibility, and convenience that families need for an adventure of a lifetime.
A successful cross-country journey requires a thoughtful pace. Rather than rushing from coast to coast, this itinerary is designed to be absorbed in distinct regional stages. The full day-by-day plan is available inside the RV PLAN app, but here is how the journey flows:
This route is packed with a diverse array of attractions suited for all ages. Here are the highlights you can expect to encounter along the way:
The outdoor adventures on this route are unparalleled. You will stand on the edge of the awe-inspiring Grand Canyon, cool off at Slide Rock State Park, and venture underground into the magnificent Caverns of Sonora. Wildlife enthusiasts will love the Flamingo Wildlife Habitat, the Arizona-Sonora Desert Museum, and the Eaton Hill Nature Center & Preserve.
History buffs will find incredible value in this journey. Early on, the Hoover Dam showcases incredible engineering. As you travel east, you will step back in time at Mission San Xavier del Bac, the legendary O.K. Corral, and the New Mexico Farm and Ranch Heritage Museum. Near the end of your trip, pay homage to the brave men and women of WWII at The National WWII Museum.
A road trip isn't complete without tasting local flavors and experiencing regional art. Grab a meal at the classic Mr D'z Route 66 Diner, sip regional varietals at Alcantara Vineyards and Winery, and take a leisurely stroll through Mesilla Plaza. For a touch of fine art, the El Paso Museum of Art offers a fantastic mid-trip cultural break.
We recommend a full 22 days for this itinerary. Covering 3,047 mi requires significant drive time, and spreading it over three weeks ensures you have ample time to explore museums, state parks, and historical sites without driver fatigue.
Absolutely. The sheer diversity of this trip—from desert canyons to Gulf Coast beaches—makes it one of the most dynamic cross-country routes available. It is heavily curated to balance natural features, family activities, and cultural heritage.
This route is perfect for families. The mix of amusement parks, wildlife watching, science sites, and swimming opportunities ensures that travelers of all ages remain engaged. Be sure to pack comfortable clothes, sturdy shoes, and plenty of sunscreen!
Because you are traversing the southern portion of the United States, spring and fall are generally the most comfortable seasons, helping you avoid the extreme summer heat of the Southwest and the peak humidity of the Southeast. For exact seasonal weather data and campground availability, check rvplan.net.
Planning a 22-day trip requires careful budgeting. When booking your motorhome, consider the size of your group; a Class C motorhome is often ideal for families, offering a great balance of living space and drivability. Because this is a point-to-point journey from the West to Florida, you will need to account for one-way drop fees in your rental agreement.
Additionally, pay close attention to mileage packages. You will be covering a minimum of 3,047 mi, so purchasing an unlimited mileage package or pre-paying for bulk miles is highly recommended. Your daily budget should also factor in fuel across seven states, nightly campground fees (a mix of state parks and private RV resorts), and entrance fees for various museums, caves, and state parks. For the most accurate, real-time pricing and availability, use the RV PLANET search tools below.
A cross-country adventure from the deserts of the West to the sunny shores of Florida is an unforgettable experience. To view the complete day-by-day itinerary, secure your ideal motorhome, and finalize your campground reservations, head over to the official trip page at RV PLANET and start planning your ultimate 22-day road trip today.
See the full polyline, drag stops to customize, and get live pricing in one click.
Open this route in RV PLAN →
| Nearby RV rental stations | Indie Campers USA - 26 E (Los Angeles (LAX area)), Travellers Autobarn USA-26 E (Los Angeles (LAX area)), Native Campervans-24 E (Los Angeles (LAX area)), El Monte-2026-E (Los Angeles (LAX area)), Cruise America- 26-E (Los Angeles (LAX area)) |
|---|---|
| Sample RV cost — 4 travelers (Class A / B / C) | {{BANDANA_PRICING_TABLE}} |
| Estimated fuel cost (total) | $950–$1,300 |
| Estimated campground cost (total) | $1,050–$1,890 |
| Estimated attractions & entrance fees — family of 4 | $400–$800 |
| Estimated groceries / self-catered food — family of 4 | $800–$1,200 |
| Live availability & pricing | Check live availability & pricing on Rent Motorhome → |
Estimate assumptions: Estimates assume a Class C motorhome averaging 10 mpg, a mix of state and private campgrounds over 21 nights, and family-of-four spending. All figures are estimates — verify on Rent Motorhome and RV PLAN for your travel dates.
A high-level look at how the route flows in stages. The exact daily stops, overnight picks, and detour options are built for you inside RV PLAN — open the route to see the full plan.

Establish a steady pace as you explore massive natural wonders, historic engineering feats, and classic Americana before dipping into Route 66 nostalgia.

Slow down to immerse yourself in the rich cultural history of the Southwest, featuring historic missions and the unique ecosystem of the Sonoran Desert.

Embrace longer driving stretches across vast plains, breaking up the journey with fascinating subterranean caves and local art hubs.

Enjoy a relaxed coastal cruising pace as you transition into lush, humid environments and dive into pivotal American history before reaching your final destination.
Total cost for this 22-day itinerary depends on the rig you pick, the pickup season, mileage add-ons, and any one-way drop-off fee across the 3,047 mi route. Check live availability and a real quote for the Los Angeles → Tampa pickup window on Rent Motorhome.
Live availability & pricing for this exact route
Prices update daily. See the full breakdown — nightly rate, taxes, one-way fee, mileage package — for your travel dates.
These are real vehicles in our Los Angeles pickup fleet that fit a multi-week western U.S. itinerary. Configure dates on rvplan.net to see live availability and the total trip cost for the exact rig you want.
| Motorhome | Class | Sleeps | Length | Transmission |
|---|---|---|---|---|
| Comfort Space Select Indie Campers USA - 26 E |
Class A - Integrated | 8 | 29.2 ft | Auto Transmission |
| R 29-31 Road Bear RV-26 E |
Class C - Alcove | 7 | 30.8 ft | Auto Transmission |
| Comfort Standard Select Indie Campers USA - 26 E |
Class C - Alcove | 7 | 24.1 ft | Auto Transmission |
| C-30 Cruise America- 26-E |
Class C - Alcove | 7 | 29.9 ft | Auto Transmission |
| Comfort Family Select Indie Campers USA - 26 E |
Class C - Alcove | 7 | 30.0 ft | Auto Transmission |
Pick your dates below and we'll open the live RV PLANET booking flow for the Los Angeles → Tampa route.
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