
Days 1-5 — The Sunshine State to the Deep South
~500–650 mi across this legTransitioning from Gulf Coast beaches and aquatic life into the forested landscapes and rivers of the South.
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| Total Days | 22 Days |
| Total Distance | 2,807 mi |
| Start & End Points | Tampa, FL to Las Vegas, NV |
| States Crossed | Florida, Mississippi, Louisiana, Texas, New Mexico, Arizona, Nevada |
| Best For | Families, couples, and long-haul slow travelers |
| Best Season | Spring and Autumn |
Embarking on a cross-country motorhome journey from Tampa to Las Vegas is a masterclass in slow travel. Spanning 2,807 mi across seven distinct states, this route offers an unparalleled transition from the breezy, aquatic life of the Gulf Coast to the rugged, neon-lit expanses of the American Southwest. RV travel is the absolute best way to experience this transect of the country, allowing you to carry your home with you as the landscape morphs from lush wetlands and historic southern estates to expansive Texas plains and ancient desert monuments. With 22 days at your disposal, you can comfortably set up camp, explore hidden gems, and truly absorb the magic of each region without feeling rushed.
To make the most of 2,807 mi, breaking the trip into manageable regional stages is essential. The detailed day-by-day plan is available inside RV PLAN, but here is a look at the overall pacing of your journey.
Your journey begins with the coastal energy of Florida before transitioning into the forested, historic corridors of the Deep South. This initial leg is characterized by short driving days, allowing plenty of time for botanical gardens, wildlife watching, and soaking in the Gulf Coast atmosphere before pushing inland.
As you cross into Mississippi and Louisiana, the focus shifts to local industry, historical sites, and river culture. The pacing remains relaxed as you navigate through areas rich in Americana, traditional dining, and unique museums that tell the story of the South.
Texas requires a shift in rhythm. The driving distances between points of interest naturally extend as you traverse the massive state. This stage is all about western heritage, expansive skies, and embracing the scale of the American frontier.
Entering the high desert, the route slows down again to allow for deep exploration of natural features and historical monuments. This leg invites you to step out of the RV for hiking and photography, exploring centuries of history etched into stone.
The final push through Arizona and into Nevada is a triumphant cruise. You will follow historic highway alignments, marvel at massive engineering feats, and finally descend into the vibrant energy of Las Vegas. The driving here is iconic and visually spectacular.
This 22-day itinerary is packed with a diverse array of experiences, perfectly suited for the flexibility of a motorhome.
Dedicating 22 days to this 2,807 mi route is the ideal timeframe. It averages out to roughly 125 miles of driving per day, which is the golden rule for relaxed RV travel. This pace allows you to enjoy morning hikes, leisurely lunches, and plenty of time to set up camp before dark.
Absolutely. If you want to experience the sheer diversity of the United States, this route delivers. You get beaches, swamps, plains, mountains, and deserts all in a single trip. The variety of attractions—from water parks and zoos for the kids to fine dining and art galleries for adults—ensures that every traveler in your group remains engaged.
This itinerary is a dream for families, retirees, and long-term travelers who appreciate slow travel. Because it connects major regions via well-maintained highways, it is highly accessible for first-time RV renters driving larger Class C or Class A motorhomes.
Spring (March to May) and Autumn (September to November) are the optimal seasons. You will avoid the extreme summer heat of the Texas and Nevada deserts, as well as the peak hurricane season in the Gulf Coast. Traveling during these shoulder seasons also means more comfortable hiking weather and easier access to popular RV campgrounds.
Planning a 22-day cross-country trip requires thoughtful budgeting, especially when organizing a one-way motorhome rental. When booking your RV, you will need to account for a one-way drop fee, as you are picking up in Tampa and returning in Las Vegas. Additionally, because this route covers 2,807 mi, pay close attention to mileage packages. Purchasing an unlimited mileage package or pre-buying your miles in bulk is often the most cost-effective strategy.
Your budget will also be shaped by your campground choices. Mixing luxurious private RV resorts (which offer amenities like pools and full hookups) with state or national park campgrounds (which offer scenic beauty at a lower nightly rate) is a great way to balance costs. For exact vehicle availability, real-time pricing, and one-way fee structures, utilize the search tools provided below.
The magic of a cross-country motorhome trip awaits. From the coastal charm of Florida to the desert lights of Nevada, this journey is guaranteed to create memories that will last a lifetime. To unlock the full day-by-day itinerary, secure your ideal vehicle, and finalize your travel plans, head over to the complete route guide: Tampa to Las Vegas RV Route Planner on RV PLANET.
See the full polyline, drag stops to customize, and get live pricing in one click.
Open this route in RV PLAN →
| Nearby RV rental stations | Use Rent Motorhome to find the closest pickup stations |
|---|---|
| Sample RV cost — 4 travelers (Class A / B / C) | {{BANDANA_PRICING_TABLE}} |
| Estimated fuel cost (total) | $950–$1,150 |
| Estimated campground cost (total) | $950–$1,400 |
| Estimated attractions & entrance fees — family of 4 | $600–$900 |
| Estimated groceries / self-catered food — family of 4 | $750–$1,100 |
| Live availability & pricing | Check live availability & pricing on Rent Motorhome → |
Estimate assumptions: Estimates assume 10 mpg fuel efficiency, an average of $55/night for campgrounds (mixing state parks and private RV resorts), and a family of four traveling during shoulder seasons. All figures are estimates — verify on Rent Motorhome and RV PLAN for your travel dates.
A high-level look at how the route flows in stages. The exact daily stops, overnight picks, and detour options are built for you inside RV PLAN — open the route to see the full plan.

Transitioning from Gulf Coast beaches and aquatic life into the forested landscapes and rivers of the South.

Exploring historical sites and local industry through the heart of the Deep South before crossing into the Lone Star State.

Immersing in authentic western heritage and expansive landscapes across the wide-open Texas plains.

Discovering striking natural monuments and ancient historical sites etched into the high desert.

Cruising iconic highways past massive engineering marvels toward the final destination of Las Vegas.
Total cost for this 22-day itinerary depends on the rig you pick, the pickup season, mileage add-ons, and any one-way drop-off fee across the 2,807 mi route. Check live availability and a real quote for the Tampa → Las Vegas pickup window on Rent Motorhome.
Live availability & pricing for this exact route
Prices update daily. See the full breakdown — nightly rate, taxes, one-way fee, mileage package — for your travel dates.
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